Useful Links

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Historically, NVP and HG have been notoriously under researched and relatively unknown. Thankfully, interest and attention in these conditions is on the rise meaning more research is being done and conversations are happening around the world.

While we can’t give you a complete library of resources, we’ve tried to compile as many references as we can. Check back regularly as we will continue to update this page.

INTERNATIONAL ORGANISATIONS

Pregnancy Sickness Support (UK)
HER Foundation (US)
Hyperemesis Ireland
ZEHG Foundation (Netherlands)
International Collaboration Hyperemesis Gravidarum


Books

MEDICATION

Ondansetron in pregnancy and risk of adverse fetal outcomes in the United States
Marlena S. Fejzo, Kimber W. MacGibbon, Patrick M. Mullin
Reproductive Toxicology May 2016


GENERAL RESEARCH ON NVP + HG

Thalidomide: a byword for tragedy
O&G Magazine Vol. 18 No 1 | Autumn 2016
Dr Debra Kennedy MBBS, FRACP, Certified Clinical Geneticist (HGSA)

Hyperemesis gravidarum
O&G Magazine Vol. 16 No 2 | Winter 2014
Dr Heena Lakhdhir FRANZCOG Trainee, Dr Jenny McDougall FRANZCOG

Nausea and vomiting in pregnancy
O&G Magazine Vol. 16 No 3 | Spring 2014
Dr Stephen Raymond FRANZCOG FRCOG

Ondansetron use in the first trimester and risk of fetal malformations
O&G Magazine Vol. 20 No 4 | Summer 2018
Dr Lynelle Taylor BSc(Hons), BMBS, FRANZCOG Adv. Trainee, Dr Cindy Ooi FRANZCOG

Preeclampsia and the use of magnesium sulphate
O&G Magazine Vol. 12 No 1 | Autumn 2010
Kristina King Undergraduate Medical Student

A patient experience of hyperemesis gravidarum and how the midwife can support her care
Essentially MIDIRS
Caitlin Dean

Leptin and leptin receptor levels in pregnant women with hyperemesis gravidarum
ANZJOG Volume 46, Issue 4 | August 2006
Nurettin AKA  Sacide ATALAY Sema SAYHARMAN  Düzgün KILIÇ Gültekin KÖSE Tuncay KÜÇÜKÖZKAN

Readmission risk and metabolic, biochemical, haematological and clinical indicators of severity in hyperemesis gravidarum
ANZJOG Volume 46, Issue 5 | October 2006
Peng Chiong TAN  Reena JACOB Kia Fatt QUEK  Siti Zawiah OMAR

Haemodialysis in Acute Renal Failure Following Hyperemesis Gravidarum
ANZJOG Volume 15, Issue 1 | February 1975
Talma Rosenthal  Vaclav Insler Adrian Iaine

Wernicke's encephalopathy due to hyperemesis gravidarum: an under‐recognised condition
ANZJOG Volume 41, Issue 4 | November 2001 
Canan Togay‐Isikay  Aytac Yigit Nermin Mutluer

A Case of Peutz‐Jeghers' Syndrome in Early Pregnancy Mimicking Hyperemesis Gravidarum
ANZJOG Volume 14, Issue 3 | August 1974
A. W. Banks

Nausea and vomiting of pregnancy: Effects on quality of life and day‐to‐day function
ANZJOG Volume 58, Issue 3 | June 2018
Amelia Tan  Sandra Lowe Amanda Henry

Clinical management of nausea and vomiting in pregnancy and hyperemesis gravidarum across primary and secondary care: a population‐based study
BJOG February 2019
L Fiaschi  C Nelson‐Piercy  S Deb R King LJ Tata

The impact of online information on health related quality of life amongst women with nausea and vomiting in pregnancy and hyperemesis gravidarum
MIDIRS Midwifery Digest Volume 24, no 2 | June 2014
Amani Saleh, Catherine Sykes

Diagnostic markers for hyperemesis gravidarum: a systematic review and metaanalysis
American Journal of Obstetrics and Gynecology Volume 211, Issue 2 | August 2014
Maartje N.Niemeijer MD Iris J.Grooten MD Nikki Vos MD Joke M.J.Bais MD Joris A.van der Post MD Ben W.Mol MD Tessa J.Roseboom PhD Mariska M.G.Leeflang PhD Rebecca C.Painter MD

Variation in hyperemesis gravidarum definition and outcome reporting in randomised clinical trials: a systematic review
BJOG Volume 125, Issue 12 | November 2018
MH Koot  RC Boelig  J van‘t Hooft  J Limpens TJ Roseboom  RC Painter IJ Grooten


GENETIC RESEARCH

Hormone receptor genes PGR and GFRAL linked to hyperemesis gravidarum
AJOG Volume 220, Issue 1 | January 2019
Marlena Fejzo, Kimber MacGibbon, Patrick Mullin

Analysis of GDF15 and IGFBP7 in Hyperemesis Gravidarum Support Causality
Geburtshilfe Frauenheilkd 2019
Marlena S. Fejzo, Peter A. Fasching, Michael O. Schneider, Judith Schwitulla, Matthias W. Beckmann, Eva Schwenke, Kimber W. MacGibbon, Patrick M. Mullin

Evidence GDF15 Plays a Role in Familial and Recurrent Hyperemesis Gravidarum
Geburtshilfe Frauenheilkd 2018
Marlena S. Fejzo, Daria Arzy, Rayna Tian, Kimber W. MacGibbon, Patrick M. Mullin

Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum
Nature Communications 2018
Marlena S. Fejzo, Olga V. Sazonova, J. Fah Sathirapongsasuti, Ingileif B. Hallgrímsdóttir, 23andMe Research Team, Vladimir Vacic, Kimber W. MacGibbon, Frederic P. Schoenberg, Nicholas Mancuso, Dennis J. Slamon & Patrick M. Mullin

Genetic analysis of hyperemesis gravidarum reveals association with intracellular calcium release channel (RYR2)
Molecular and Cellular Endocrinology September 2016
Marlena Schoenberg Fejzo, Ronny Myhre, Lucía Colodro-Conde, Kimber W. MacGibbon, Janet S. Sinsheimer, M.V. Prasad Linga Reddy, Paivi Pajukanta, Dale R. Nyholt, Margaret J. Wright, Nicholas G. Martin j, Stephanie M. Engel, Sarah E. Medland, Per Magnus, Patrick M. Mullin

Recurrence Risk of Hyperemesis Gravidarum
National Institute of Health 
J Midwifery Womens Health Author manuscript

Change in Paternity and Recurrence of Hyperemesis Gravidarum
The Journal of Maternal-Fetal and Neonatal Medicine 2011
Marlena S. Fejzo, ChunYu Ching, Frederic P. Schoenberg, Kimber Macgibbon, Roberto Romero, T. Murphy Goodwin, Patrick M. Mullin

Familial aggregation of hyperemesis gravidarum
AJOG 2010
Yafeng Zhang, MS; Rita M. Cantor, PhD; Kimber MacGibbon, RN; Roberto Romero, MD;
Thomas M. Goodwin, MD; Patrick M. Mullin, MD, MPH; Marlena S. Fejzo, PhD

High prevalence of severe nausea and vomiting of pregnancy and hyperemesis gravidarum among relatives of affected individuals
EJOG Volume 141, Issue 1 | November 2008 
Fejzo MS, Ingles SA, Wilson M, Wang W, MacGibbon K, Romero R, Goodwin TM

Familial Aggregation of Hyperemesis Gravidarum
American Journal of Human Genetics, Volume 69 Number 4 | October 2001
Marlena Schoenberg Fejzo, Kimber MacGibbon, Frederic Schoenberg Paik


RISKS + OUTCOMES

Prenatal exposure to hyperemesis gravidarum linked to increased risk of psychological and behavioral disorders in adulthood
Journal of Developmental Origins of Health and Disease
P. M. Mullin, A. Bray, F. Schoenberg, K. W. MacGibbon, R. Romero, T. M. Goodwin and M. S. Fejzo

Analysis of neurodevelopmental delay in children exposed in utero to hyperemesis gravidarum reveals increased reporting of autism spectrum disorder
Reproductive Toxicology 84 2019
Marlena Fejzo, Alyssa Kam, Amanda Laguna, Kimber MacGibbon, Patrick Mullin

Analysis of pre- and post-pregnancy issues in women with hyperemesis gravidarum
Autonomic Neuroscience: Basic and Clinical 2016
Rayna Tian, Kimber MacGibbon, Bhuvan Martin, Patrick Mullin, Marlena Fejzo

Mortality Secondary to Hyperemesis Gravidarum: A Case Report
Women’s Health & Gynecology November 2015
MacGibbon KW, Fejzo, MS, and Mullin PM

Neurodevelopmental delay in children exposed in utero to hyperemesis gravidarum
European Journal of Obstetrics & Gynecology and Reproductive Biology 2015
Marlena S. Fejzo, Aromalyn Magtira, Frederic Paik Schoenberg, Kimber Macgibbon, Patrick M. Mullin

Intestinal obstruction is a rare complication of ondansetron exposure in hyperemesis gravidarum
Reproductive Toxicology December 2014
Marlena S. Fejzo, Kimber MacGibbon, Patrick Mullin

Psychiatric factors do not affect recurrence risk of hyperemesis gravidarum
Journal of Obstetrics and Gynaecology Research 2014
Aromalyn Magtira, Frederic Paik Schoenberg, Kimber MacGibbon, Khalil Tabsh and
Marlena S. Fejzo

Antihistamines and other prognostic factors for adverse outcome in hyperemesis gravidarum
European Journal of Obstetrics & Gynecology and Reproductive Biology 2013
Marlena S. Fejzo, Aromalyn Magtira, Frederic Paik Schoenberg, Kimber MacGibbon, Patrick Mullin, Roberto Romero, Khalil Tabsh

Risk factors, treatments, and outcomes associated with prolonged hyperemesis gravidarum
The Journal of Maternal-Fetal and Neonatal Medicine 2011
Patrick M. Mullin, ChunYu Ching, Frederic Schoenberg, Kimber MacGibbon, Roberto Romero, T. Murphy Goodwin & Marlena S. Fejzo

Posttraumatic stress symptoms following pregnancy complicated by hyperemesis gravidarum
The Journal of Maternal-Fetal and Neonatal Medicine 2011
Joan Christodoulou-Smith, Jeffrey I. Gold, Roberto Romero, Thomas M. Goodwin, Kimber W. MacGibbon, Patrick M. Mullin, Marlena S. Fejzo

Symptoms and Pregnancy Outcomes Associated with Extreme Weight Loss among Women with Hyperemesis Gravidarum
Journal of Women’s Health, Volume 18, Number 12 | 2009
Marlena S. Fejzo, Ph.D., Borzouyeh Poursharif, M.D., Lisa M. Korst, M.D., Shari Munch, Ph.D.,
Kimber W. MacGibbon, R.N., Roberto Romero, M.D., and T. Murphy Goodwin, M.D

Patients with a history of hyperemesis gravidarum have similar symptoms during egg stimulation and develop ovarian hyperstimulation syndrome: case series
American Society for Reproductive Medicine
Marlena S. Fejzo, Ph.D., Roberto Romero, M.D., and T. Murphy Goodwin, M.D.

Elective pregnancy termination in a large cohort of women with hyperemesis gravidarum
Contraception Issue 76 2007
Borzouyeh Poursharif, Lisa M. Korst, Kimber W. MacGibbon, Marlena S. Fejzo, Roberto Romero, T. Murphy Goodwin

The psychosocial burden of hyperemesis gravidarum
Journal of Perinatology 2007
B Poursharif, LM Korst, MS Fejzo, KW MacGibbon, R Romero and TM Goodwin